Heterogeneity of Myocardial ATP Flux Rate via CK In Vivo Porcine Hearts with hiPSC Tri-lineage Cell Transplantation Using 2D CSI P-31 MR Spectroscopy
Weina Cui 1 , Lei ye 1 , Albert Jang 1 , Pengyuan Zhang 1 , Qiang Xiong 1 , and Jianyi Zhang 1
Department of Medicine/cardiology,
University of Minnesota, minneapolis, MN, United States
We investigated the functional impact of combined
intramyocardial transplantation of cardiomyocytes,
endothelial cells, and smooth muscle cells derived from
hiPSCs to a porcine model of ischemia reperfusion (I/R).
It was demonstrated that ATP turnover rate could be
measured with two components, the creatine reaction rate
and ATP hydrolysis rate, even without measuring Pi
levels. MI injury has a heterogeneous effect on
myocardial bioenergetics. The border zone PCr/ATP ratio
is improved in the cell treated group compared with open
patch group. The Kpcr
in the border zone is slightly increased in cell treated
group compared with patch only group.
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