Abstract #4484
High resolution quantitative spiral CMR perfusion imaging demonstrates a reduced endocardial to epicardial perfusion gradient and myocardial flow reserve in patients with microvascular disease
Michael Salerno 1,2 , Yang Yang 3 , Peter Shaw 4 , Angela Taylor 4 , Craig Meyer 3 , Fred Epstein 3 , and Christopher Kramer 4,5
1
Medicine, Cardiology, University of
Virginia, Charlottesville, VA, United States,
2
Radiology,
University of Virginia, Charlottesville, VA, United
States,
3
Biomedical Engineering, University of
Virginia, VA, United States,
4
Medicine,
Cardiology, University of Virginia, VA, United States,
5
Radiology,
University of Virginia, VA, United States
Patients with non-obstructive coronary artery disease
may have abnormal myocardial perfusion reserve (MPR)
resulting from microvascular disease (MVD). Reduced MPR
as demonstrated by PET is a significant predictor of
cardiac death. CMR has the unique ability to quantify
transmural differences in perfusion given its high
spatial resolution providing new insights into MVD. We
developed a high resolution (1.5mm) quantitative spiral
perfusion pulse sequence and performed vasodilator
stress in patients with a high likelihood of MVD. We
demonstrate an abnormal stress endocardial to epicardial
perfusion gradient as well as abnormal MPR in these
patients.
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