Abstract #0218

High-Frequency and Other Pathological Network Hemodynamics Observed in Epilepsy Patients Imaged With Multi-Band Multi-Echo BOLD Functional MRI at 7T

Prantik Kundu^1,2, Lara V. Marcuse³, Bradley Delman¹, Rebecca Feldman¹, Madeline C. Fields³, and Priti Balchandani¹

¹Department of Radiology, Icahn School of Medicine at Mt. Sinai, New York, NY, United States, ²Department of Psychiatry, Icahn School of Medicine at Mt. Sinai, New York, NY, United States, ³Department of Neurology, Icahn School of Medicine at Mt. Sinai, New York, NY, United States

Clinical assessment of epilepsy based on extra-cranial EEG electrophysiology has moderate diagnostic sensitivity (40%), poor spatial specificity (1-5 cm), and no prognostic value. We seek to utilize MRI for more effective non-invasive characterization of epilepsy than currently established. We implemented multi-echo multi-band (MEMB) BOLD fMRI at 7T to map the hemodynamic signatures of seizure zones and networks in spontaneous brain activity of focal epilepsy patients versus matched controls. We mapped seizure networks in patients at millimeter-resolution, and observed epileptiform BOLD to have significantly amplified infra-slow and high-frequency temporal oscillations, analogous to characteristic epileptiform activity from EEG.

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