Yue Cao1,2, Daniel Wahl1, Priyanka Pramanik1, Michelle Kim1, Theodore S Lawrence1, and Hemant Parmar2
1Radiaiton Oncology, University of Michigan, Ann Arbor, MI, United States, 2Radiology, University of Michigan, Ann Arbor, MI, United States
It is a
challenge to differentiate non-enhanced components of glioblastoma (GBM) from
edema and normal tissue using conventional MRI.
The ill-differentiation could lead to inadequate treatment for GBM by surgery
and radiation therapy. This study evaluated
the enhanced and non-enhanced hypercellular volume (HCV) of GBM identified by
high b-value diffusion weighted (DW) imaging with gross tumor volume defined on
post-Gd T1 weighted images, abnormality volume on T2 FLAIR images, high dose
coverage planned according to conventional MRI, and progression. This study found that the HCV was an aggressive
component of GBM and predicted progression free survival.