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Abstract #0809

Measuring Subtle Leakage in Patients with Cerebrovascular Disease Using Dual Temporal Resolution DCE-MRI: Is it Reproducible?

Sau May Wong1, Jacobus F.A. Jansen1, C. Eleana Zhang2, Julie Staals2, Paul A.M. Hofman1, Joachim E. Wildberger1, Robert J. van Oostenbrugge2, C├ęcile R.L.P.N. Jeukens1, and Walter H. Backes1

1Radiology & Nuclear Medicine, Maastricht University Medical Centre, Maastricht, Netherlands, 2Neurology, Maastricht University Medical Centre, Maastricht, Netherlands

Measuring subtle leakage through the blood-brain barrier using DCE-MRI is challenging since their magnitude is lower than in high-grade tumors. To have a clinical application, this method has to be reproducible. The reproducibility of the transfer constant (Ki) and fractional plasma volume (vp) using dual temporal resolution DCE-MRI was investigated in 14 patients with cerebrovascular disease. Low CVs and moderate to high ICCs demonstrate that despite the noisy nature of the measurement, the method is moderately reproducible. Still, cautious interpretation of the Ki and vp in individual patients is needed. Day-to-day variations may be partly compensated by using session-averaged VIFs.

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