Abstract #0836

Metabolic profiling of the tumor interstitial fluid using NMR: contribution of breast cancer subtypes and VEGF overexpression

Santosh K Bharti¹, Louis Dore-Savard¹, Aleksander S Popel², and Zaver M Bhujwalla¹

¹The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, Division of Cancer Imaging Research, Baltimore, MD, United States, ²Department of Biomedical Engineering, Johns Hopkins University, School of Medicine, Systems Biology Laboratory, Baltimore, MD, United States

Interstitial fluid (IF) is a key component of the tumor microenvironment (TME) that encompasses the secretome and holds the key to several of the phenotypic traits of cancer. Modern analytical methods like 1H MR spectroscopy (MRS) allow for comprehensive metabolic characterization of tissue, cell, and bio-fluids content to better understand the TME and cancer metabolism. Here, for the first time, we have metabolically characterized TIF from triple negative and estrogen receptor (ER)-positive human breast tumor xenografts with or without VEGF overexpression and detected significant differences between tumor types and with VEGF overexpression.

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