Reduced Cortical and Thalamic Cerebral Blood Flow in Adolescents with Chronic Post-Concussive Symptoms
Samuel Barnes1, Brenda Bartnik-Olson1, Barbara Holshouser1, and Stephen Ashwal2
1Radiology, Loma Linda University, Loma Linda, CA, United States, 2Pediatric Neurology, Loma Linda University, Loma Linda, CA, United States
Several studies have
shown regions of hypoperfusion in symptomatic patients in the chronic phase of
mild TBI. In
this study we used whole-brain spatial mapping and a voxel-wise statistical approach to
investigate the extent and anatomical distribution of cerebral hypoperfusion in
chronic symptomatic pediatric concussion subjects. Our findings identified multiple areas of
reduced CBF, incorporating both the cerebral cortex and subcortical
regions. Compared to our previous results using region of interest analysis, we detected a greater number of areas of hypoperfusion suggesting that the use of whole-brain spatial mapping and voxel-wise analysis improved detection of CBF abnormalities. We
speculate that hypoperfusion in these regions may be implicated in cognitive deficits in these subjects.
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