Abstract #0863

Hyperpolarized 13C Metabolic imaging of neuroinflammation in Traumatic Brain Injury

Caroline Guglielmetti^1,2, Austin Chou¹, Annemie Van der Linden², Susanna Rosi¹, and Myriam M Chaumeil¹

¹University of California San Francisco, San Francisco, CA, United States, ²University of Antwerp, Antwerp, Belgium

This study demonstrates that ¹³C MRS of hyperpolarized pyruvate can be used to detect increased lactate production from pro-inflammatory macrophages in a preclinical model of Traumatic Brain Injury, hence providing a novel tool for in vivo detection of neuroinflammation.

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