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Abstract #0898

In-vivo evaluation of hypometabolism associated with muscular dystrophy using Creatine CEST MRI

Rong-Wen Tain1,2, Ahlke Heydemann3,4, Alessandro Scotti1,5,6, Weiguo Li7,8, Xiaohong Joe Zhou1,5,6,9, and Kejia Cai1,5,6

1Radiology,College of Medicine, University of Illinois, Chicago, IL, United States, 23T Research Program, Center for MR Research, College of Medicine, University of Illinois, Chicago, IL, United States, 3Physiology & Biophysics,College of Medicine, University of Illinois, Chicago, IL, United States, 4Center for Cardiovascular Research, College of Medicine, University of Illinois, Chicago, IL, United States, 53T Research Program, Center for MR Research, University of Illinois, Chicago, IL, United States, 6Bioengineering, University of Illinois, Chicago, IL, United States, 7Research Resource Center, University of Illinois, Chicago, IL, United States, 8Radiology, Northwestern University, Chicago, IL, United States, 9Neurosurgery, University of Illinois, Chicago, IL, United States

This study aims to measure hypometabolism in the muscle due to muscular dystrophy using creatine CEST MRI. We acquired images of the lower limbs from the diseased and wild-type mice. Differences in the Z-spectrum and creatine CEST contrast map were seen between fibrotic and normal muscles. This suggested that CrCEST MRI may serve as a sensitive imaging biomarker for metabolic changes associated with muscular dystrophy.

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