Poonam Rana1, Ritu Tyagi1, Apurva Watve1, Sujeet Kumar Mewar2, Uma Sharma2, N. R. Jagannathan2, and Subash Khushu1
1NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO, Delhi, India, 2Department of NMR, All India Institute of Medical Sciences (AIIMS), Delhi, India
Increasing radiation exposure is a big threat
to population worldwide. The present study predicts the early predictive
biomarker for radiation injury using 1H NMR based metabolomics. The
animals were exposed to 7.5 Gy whole body radiation. The variable importance of
projection (VIP) score showed six most significant metabolites having VIP score
of >1. The partial least square discriminant
analysis (PLS-DA) based receiver-operating
characteristic (ROC) curve of all the six metabolites showed taurine
with highest area under curve (AUC) value of 0.996 and with sensitivity (100%)
and specificity (90%). It could be used as early prognostic biomarker for
radiation injury.
