Filtered serum-based metabolomics of prostate cancer using 1H NMR spectroscopy
Ashish Gupta1, Deepak Kumar1, Anil Mandhani2, and Satya Narain Sankhwar3
1metabolomics, Centre of Biomedical Research, Lucknow, India, 2Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, 3Urology, King George’s Medical University, Lucknow, India
To
address the shortcomings of clinical indexes for the precise identification of
prostate cancer (PC) and differentiation from benign prostatic hyperplasia
(BPH) and healthy controls (HC), we applied 1H NMR spectroscopy as a
surrogate tactic for probing of PC and BPH. The study comprises filtered sera
from PC (n=75), BPH (n=70) and the HC (n=65). NMR-measured metabolites and
clinical evaluation data were examined separately using multivariate
discriminant function analysis (DFA) to probe the signature descriptors for
each cohort. DFA reveals that filtered serum based metabolic profiling can
differentiate not only HC from BPH and PC but also BPH from PC.
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