Abstract #0952

Functional connectivity self-regulation of cerebellum and primary motor area with fMRI-Brain Computer Interfaces. Pilot results.

Patricia Andrea Vargas^1,2, Ranganatha Sitaram^1,3,4,5, Pradyumna Sepúlveda^2,6, Cristian Montalba², Mohit Rana¹, Cristián Tejos^2,6, and Sergio Ruiz^1,3

¹Department of Psychiatry, Faculty of Medicine, Interdisciplinary Center for Neuroscience, Pontificia Universidad Católica de Chile, Santiago, Chile, ²Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile, ³Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen, Germany, ⁴Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum, India, ⁵Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, ⁶Department of Electrical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile

In recent years there is a growing interest in the potential application of Brain-Computer interfaces (BCI) for psychiatric and neurological disorders. After stroke, if the primary motor cortex (M1) is affected, it is common to find a “deactivation” of the contralateral cerebellum.

The aim of this study was to evaluate the feasibility of achieving volitional control of M1-cerebellum functional connectivity, in healthy subjects with an fMRI-BCI system.

The results indicate that volitional self-regulation of cerebellum-M1 connectivity is feasible with fMRI-BCI. The data also suggests that cerebellum is more easily recruited than M1.

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