Abstract #0953

Connectivity-based parcellation of nucleus accumbens into putative core and shell guiding for stereotactic target localization and alterations in each NAc subdivision in mTLE patients

Xixi Zhao¹, Junling Wang¹, Xiangliang Tan¹, Xiang Xiao¹, Zeyu Zheng¹, Yingjie Mei², Queenie Chan³, Yikai Xu¹, Ru Yang⁴, and Qianjin Feng⁴

¹Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, People's Republic of, ²Philips Healthcare, Guangzhou, China, People's Republic of, ³Philips Healthcare, HongKong, China, People's Republic of, ⁴2School of Biomedical Engineering and Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China, People's Republic of

NAc was supposed be involved in epileptogenesis, especially shell portion. The exact parcellation within the NAc and structural alterations in vivo of NAc subdivisions in EP patients remains unclear. We used diffusion probabilistic tractography to subdivide NAc into putative core shell subdivisions in individual mTLE patients for guiding NAc shell stereotactic target localization. Our results revealed that both left and right mTLE patients exhibited decreased FA and increased MD in shell portion of bilateral NAc, which may reflect neuronal degeneration and damage caused by seizure mainly in shell portions, and suggest a possible role of the NAc shell in epileptogenesis

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