Abstract #0999

Non-contrast Vasodilatory Response Assessment in a porcine model of Acute Myocardial Infarction using Arterial Spin Labeled CMR

Hung Phi Do¹, Venkat Ramanan², Graham A Wright^2,3, Nilesh R Ghugre^2,3, and Krishna S Nayak⁴

¹Department of Physics and Astronomy, University of Southern California, Los Angeles, CA, United States, ²Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, ³Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁴Ming Hsieh Department of Electrical Engineering, University of Southern California, Los Angeles, CA, United States

Myocardial vasodilatory response is an important indicator of microvascular function and viability. Arterial spin labeled (ASL) CMR is a non-contrast method that can quantify myocardial blood flow making it attractive to study vasodilatory response. In this work, we demonstrate the feasibility of ASL in the assessment of regional vasodilatory response in a porcine model of acute myocardial infarction (AMI) using a pharmacological stress agent. Quantitative monitoring of microvascular function in the infarcted, salvageable and remote myocardial territories may potentially help identify patients who are prone to adverse long-term remodeling post-AMI.

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