Abstract #1006

Fast measurement of blood T1 in the internal carotid artery at 3T

Wenbo Li^1,2, Peiying Liu¹, Hanzhang Lu¹, John J. Strouse³, Peter C.M. van Zijl^1,2, and Qin Qin^1,2

¹Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Division of Pediatric Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

The knowledge of arterial blood T1 is important to quantify cerebral blood flow with ASL or the inversion time for VASO experiments. We used a fast blood T1 protocol to measure the arterial T1 values in the internal carotid artery in vivo. Ex-vivo experiments were conducted to validate our method. Excellent correlation and agreement was found between in vivo and ex vivo results. The group-averaged arterial blood T1 value over 9 healthy volunteers was 1864+/-92ms (Hct=0.41+/-0.04), which is 200 ms longer than the widely adopted number obtained from bovine blood experiments. The arterial T1 value per subject was found to have significant correlation with the individual Hct values.

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