Lukas Reinhold Buschle1, Felix Tobias Kurz1,2, Thomas Kampf3, Heinz-Peter Schlemmer1, and Christian Herbert Ziener1
1E010 Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany, 3Department of Experimental Physics 5, University of Würzburg, Würzburg, Germany
We analyze the local line shape in human lung
tissue in dependence of the underlying microscopic tissue
parameters such as diffusion coefficient, alveolar size and susceptibility
difference. The interplay between susceptibility- and diffusion-mediated
effects is discussed in several dephasing regimes. In vivo measurements for human lung tissue show an excellent agreement with simulations of the dephasing process. This allows an
improved quantitative diagnosis of early pulmonary fibrosis and emphysema.
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