Response of MR Contrast Parameters in Tissues and Tissue Mimicking Phantoms to Histotripsy
Steven P Allen1, Luis Hernandez-Garcia2, Charles A Cain1, and Timothy L Hall1
1Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, 2fMRI Lab, University of Michigan, Ann Arbor, MI, United States
We estimate the R2 relaxation rate and the
apparent diffusion coefficient at 7T in a variety of in vitro tissues and
tissue mimicking phantoms after they have been subjected to homogenization by
ultrasonic cavitation (histotripsy). The estimated R2 rate of these lesions decreases
with increased treatment so long as the lesions are made in materials with high
iron content. When lesions are made in brain tissue or phantoms with low iron
content, the R2 rate remains unperturbed by homogenization. The apparent
diffusion coefficient increases with increasing treatment for all tissues and phantoms.
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