Pawan Kumar1, Sadhana Kumari1, Senthil S Kumaran1, Shefali Chaudhary1, Vinay Goyal2, Madhuri Behari2, S N Dwivedi3, Achal Srivastava2, and Naranamangalam R Jagannathan1
1Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, India, 2Department of Neurology, All India Institute of Medical Sciences, New Delhi, India, 3Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India
We used 1H NMR technique to investigate
the serum samples of 6 patients with Parkinson’s disease (PD) and 6 healthy
controls (HC) using 700 MHz NMR spectrometer and the data were processed using
the Agilent software, Vnmrj2.3A. PLS-DA multivariate analysis was performed to
explore biochemical dissimilarities between PD patients and HC using
MetaboAnalyst (3.0) software. We observed significantly elevated levels of lactate,
glutamate and methyl guanidine PD patients in comparison with HC on t-test, suggesting
protein metabolism impairment, mitochondrial dysfunction and oxidative stress
in PD patients.
