Abstract #2417

A Proton Magnetic Resonance Study to Investigate Dietary Influences on Blood Plasma of patients with Celiac Disease

Uma Sharma¹, Deepti Upadhyay¹, Govind Makharia², Prasenjit Das³, Siddharth Datta Gupta³, and Naranamangalam R Jagannathan¹

¹Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, India, ²Department of Gastroenterology and human Nutrition, All India Institute of Medical Sciences, New Delhi, India, ³Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

The present study demonstrated dietary induced variations on the metabolic profile of blood plasma of CeD patients. Increased valine was seen in CeD non-vegetarians compared to CeD vegetarians. Both CeD vegetarians and non-vegetarians showed increased concentrations of gluconeogenic amino acids like alanine and glycine compared to healthy subjects. Increased pyruvate and creatine in CeD vegetarians compared to healthy vegetarians indicates impaired energy supply. Decreased creatinine in CeD vegetarians and non-vegetarians compared to healthy subjects is due to protein malabsorption in CeD. The study illustrates the nutritional status of CeD patients and healthy subjects on the basis of their dietary intake.

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