Use of iron contrast agents to detect brain tumor treatment response based on stimulating the innate immune system
Yang Runze1,2, Susobhan Sarkar2, Daniel J Korchinski1, Ying Wu1, V Wee Yong2,3, and Jeff F. Dunn1,2
1Radiology, University of Calgary, Calgary, AB, Canada, 2Clinical Neuroscience, University of Calgary, Calgary, AB, Canada, 3Oncology, University of Calgary, Calgary, AB, Canada
Multiforme (GBM) is the most aggressive brain cancer with an abysmal prognosis.
It has been shown that monocytes can be activated to suppress GBM stem cells
using Amphotericin B (Amp B). We propose that monocytes can be labeled using intravenous
injection of ultra-small iron oxide nanoparticles (USPIO), which will allow us
to detect a rapid treatment response. We showed that Amp B treated animals significantly
decreased T2* compared to vehicles, showing the presence of USPIO within the
tumor. This shows that USPIO can be an effective tool to monitor cancer
therapies that stimulate innate immunity.
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