Abstract #2436

Diffusion weighted magnetic resonance imaging as an early predictor of survival in patients with liver-dominant metastatic colorectal cancer following 90-Yttrium-microsphere radioembolization

Frederic Carsten Schmeel¹, Birgit Simon¹, Julian Alexander Luetkens¹, Frank Träber¹, Leonard Christopher Schmeel¹, Hans Heinz Schild¹, and Dariusch Reza Hadizadeh¹

¹Department of Radiology, University Hospital Bonn, Bonn, Germany

Imaging-based response assessment to local interventional therapies is essential for further therapy decisions in patients with advanced malignancies. Therefore, we investigated whether early post-therapeutic changes in diffusion-weighted MRI using quantifications of the apparent diffusion coefficient (ADC) could predict the outcome of patients with liver-dominant metastatic colorectal cancer after radioembolization with 90-Yttrium microspheres (RE). Uni- and multivariate survival analyses were performed comparing various variables with potential impact on overall survival. Our results reveal that an increase in the post-therapeutic minimal ADC remained the strongest and only independent predictor of overall survival shortly after radioembolization.

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