Abstract #2648

Characterization of Renal Tumors: Initial Experience Integrating Biomechanical and Morphological Assessment Using 3 Tesla Magnetic Resonance Imaging and Elastography (MRE)

Davide Prezzi¹, Radhouene Neji², James Stirling¹, Sami Jeljeli¹, Hema Verma³, Tim O'Brien⁴, Ben Challacombe⁴, Ashish Chandra⁵, Vicky Goh¹, and Ralph Sinkus¹

¹Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, ²MR Research Collaborations, Siemens Healthcare, Frimley, United Kingdom, ³Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, ⁴Urology Centre, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, ⁵Department of Histopathology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom

Incidentally detected renal tumors are overtreated surgically, as up to 15% of them are benign, most frequently oncocytomas. We hypothesize that integrating biomechanical with morphological MRI assessment can improve lesion characterization, precluding unnecessary surgery. Initial experience and pathological correlation in four resected renal oncocytomas and renal cell carcinomas (RCC) demonstrate that 30Hz MRE with shear modulus elastography parametric mapping is feasible, correlating spatially with gross pathology, with lower viscosity/elasticity (y) ratios [mean = 0.22] in malignant RCCs compared to oncocytomas [mean = 0.46], showing promise for clinical application.

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