Abstract #2649

Integrating dynamic contrast-enhanced magnetic resonance imaging and diffusion kurtosis imaging for neoadjuvant chemotherapy assessment in nasopharyngeal carcinoma

Dechun Zheng¹, Yunbin Chen¹, Meng Liu¹, Qiuyuan Yue¹, Xiaoxiao Zhang¹, Hao Lin¹, Xiangyi Liu¹, Wang Ren¹, Weibo Chen², and Queenie Chan³

¹Radiology, Fujian Provincial Cancer Hospital, Fuzhou, China, People's Republic of, ²Philips Healthcare, Shanghai, China, People's Republic of, ³Philips Healthcare, Hong Kong, Hong Kong

DKI is an emerging technique and shows advantage than traditional DWI. Prior DCE-MRI studies suggested it had utility in early monitoring radiotherapy and chemotherapy sensitivity in anti-tumor treatment. However, there are a few studies investigated whether a combination of multi-modalities functional MRI techniques could improve diagnostic efficacy for prediction of anti-tumor outcome. This study enrolled 53 patients who received both DCE-MRI and DKI exams during NAC courses and suggested there were collaboration between DCE-MRI and DKI to early monitor NAC treatments in NPC. In addition, two NAC cycles is a better time point to non-invasive assess NAC response using fMRI.

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