Ileana Hancu1, Elizabeth Morris2, Christopher Sevinsky1, Fiona Ginty1, and Sunitha Thakur2
1GE Global Research Center, Niskayuna, NY, United States, 2Memorial Sloan Kettering Cancer Center, New York City, NY, United States
Differential expression
of lipid metabolism genes was recently reported in breast cancer patients. In
this pilot study, single voxel MRS data was used to assess the spatial and
spectral lipid profile of normal volunteers and subjects undergoing neo-adjuvant
chemotherapy. Statistically significant differences in lipid profiles from
different voxels in single volunteers and between volunteers were found. Moreover,
some lipid peak ratios provided good tumor/normal tissue separation. MRI/MRS-based
profiling of lipid metabolism may provide a unique tool for better breast
cancer tumor detection and characterization.
