Differentiating Contributions To Diffusional Kurtosis with Symmetrized Double-PFG MRI
Jeffrey Louis Paulsen1, Iris Yuwen Zhou2, Yi-Qiao Song1, and Phillip Zhe Sun2
1Schlummerger-Doll Research, Boston, MA, United States, 2Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States
Kurtosis imaging enables valuable diagnostics of stroke
and other tissue pathologies. It can arise
both directly from restricted diffusion, and indirectly from averaging multiple
microscopic environments. We develop an EPI imaging sequence utilizing
double diffusion contrast that isolates the direct contribution. We demonstrate consistency with traditional kurtosis imaging in phantoms yet unique contrast
in-vivo in a live rat brain.
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