Abstract #3043

Whole-body diffusion weighted imaging in multiple myeloma: Temporal changes of Gaussian and non-Gaussian diffusion parameters following treatment. Initial experience at 3.0T

Arash Latifoltojar¹, Margaret Hall-Craggs², Nikolaos Dikaios¹, Kwee Yong¹, Neil Rabin², Alan Bainbridge², Magdalena Sokolska², and Shonit Punwani¹

¹University College London, London, United Kingdom, ²University College London Hospital, London, United Kingdom

Diffusion weighted imaging's apparent diffusion coeffiecient (ADC) has been shown to be a potential imaging biomarker for monitoring treatment response in multiple myeloma. However, in most instances, a mono- exponential fitting model is used to assess temporal changes. In this work, we investigated the Gaussian and non-Gaussian fitting algorithms and their respective quantitative biomarkers for assessing response in multiple myeloma using whole body diffusion weighted imaging.

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