Eric T Peterson1, Natalie M Zahr1,2, Dongjin Kwon1, Matthew Serventi1, Cheshire Hardcastle1, Edith V Sullivan2, and Adolf Pfefferbaum1
1Biosciences, SRI International, Menlo Park, CA, United States, 2Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States
This work investigates the inter- and intra-session
repeatability and the effects of age on intra voxel incoherent motion (IVIM)
parameters. Atlas registration allowed for parcellation-based region specific
brain analysis. A new and robust fitting approach reliably identified the
perfusion fraction, diffusion, and pseudo-perfusion parameters from 15 healthy
normal volunteers. The results show that IVIM is repeatable and that the
perfusion fraction, diffusion, and pseudo-perfusion parameters are significantly higher in
older than younger adults in several brain regions, most likely from perivascular
CSF infiltration. This work serves to highlight how age is an important factor to consider
when using IVIM.
