Malgorzata Marjanska1, J. Riley McCarten2, Laura Hemmy2, Dinesh K Deelchand1, and Melissa Terpstra1
1University of Minnesota, Minneapolis, MN, United States, 2Minneapolis VA Medical Center, Minneapolis, MN, United States
The
goal of this work was to characterize differences in the concentrations of
neurochemicals beyond tNAA, tCr, and tCho in the OCC and PCC regions of healthy
young and elderly subjects. The key innovation was scanning at ultra-high field
(7 T) at very short echo time. The observed differences are consistent with
compromised neurons (NAA, NAAG, Glu and GABA), membrane turnover (PE and tCho),
oxidative stress (lower GSH in the OCC), inflammation (mIns), altered energy
metabolism (tCho and Glc), and changes in large molecules (Mac).
