Peter Andrew Hardy1, Christopher J Norsigian2, Walter Witschey3, and Luke H Bradley2
1Radiology, University of Kentucky, Lexington, KY, United States, 2Anatomy & Neurobiology, University of Kentucky, Lexington, KY, United States, 3Smilow Center for Translational Research, University of Pennsylvania, Philadelphia, PA, United States
Developing tissue mimicking materials can be helpful in reducing the cost and duration of experiments which otherwise require animals. We tested a variety of agarose gels of different gel strength as suitable tissue mimicking material for convection enhanced delivery. The results demonstrate a significant difference in infusion volume and we relate that, through MR measurements, to the mechanical stiffness of the gels.
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