A four-layer boundary element model for MRI-guided transcranial magnetic stimulation
Aapo Nummenmaa1 and Matti Stenroos2
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland
MRI-guided targeting and dosing has the potential increase the
consistency and efficacy of transcranial magnetic stimulation (TMS). We propose
a boundary element method (BEM) approach for estimating the TMS-induced cortical
electric fields (E-fields). The method can be applied based on standard T1/T2-weighted
MRI data and can incorporate the cerebrospinal fluid (CSF) as a separate conductivity
compartment. Our results show that the CSF layer may increase the estimated
E-field amplitudes up to 25%. The effect of the CSF depends on the location and
orientation of the TMS coil/target in a rather intricate manner, highlighting
the importance of individualized, realistically shaped models.
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