Abstract #3673

In-vivo Assessment of Lung Injury Using Hyperpolarized Carbon-13 MRI in a Two-hit Model of Acid Aspiration and VILI

Mehrdad Pourfathi^1,2, Yi Xin¹, Stephen J Kadlecek¹, Maurizio Cereda³, Harrilla Profka¹, Sarmad M Siddiqui^1,4, Hooman Hamedani^1,4, and Rahim R Rizi¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA, United States, ³Anesthesiology and Critical Care, University of Pennsylvania, Perlman School of Medicine, Philadelphia, PA, United States, ⁴Bioengineering, University of Pennsylvania, Philadelphia, PA, United States

Ventilator induced lung injury (VILI) results from mechanical trauma and secondary inflammatory responses. Previous imaging studies focused on the effects of ventilator settings on structural or functional changes; however, no MRI studies have been conducted to elucidate the metabolic changes during VILI. In this study, the potential of HP [1-¹³C]-pyruvate and its conversion to [1-¹³C]-lactate as a marker for the lung inflammation was investigated in a two-hit model of acid aspiration and VILI.

This abstract and the presentation materials are available to members only; a login is required.

Join Here

­In-vivo Assessment of Lung Injury Using Hyperpolarized Carbon-13 MRI in a Two-hit Model of Acid Aspiration and VILI

In-vivo Assessment of Lung Injury Using Hyperpolarized Carbon-13 MRI in a Two-hit Model of Acid Aspiration and VILI