1Psychiatry, University of Pennsylvania, Philadelphia, PA, United States, 2Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, China, People's Republic of
entropy (BEN) mapping provides a way to characterize temporal brain dynamics,
and thus the health of regional brain functionality. In this study, we aimed to
examine its sensitivity for differentiating Alzheimer’s disease (AD) from
healthy controls, as well as its relationship to AD severity. We found reduced BEN
in the limbic and prefrontal area in AD compared to controls, and a negative
correlation between BEN and AD severity in a widespread area of neural cortex.
These results suggest BEN as a potential biomarker for AD.