Sebastian C. Niesporek1, Reiner Umathum1, Thomas M. Fiedler1, and Armin M. Nagel1,2
1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Diagnostic and Interventional Radiology, University Medical Center Ulm, Ulm, Germany
Functional
information of cell and tissue viability can be obtained via dynamic 17O-MRI. The
quantification of H217O-concentration as a turnover product of oxidative
phosphorylation in combination with 17O2-inhalation enables mapping of the cerebral
metabolic rate of oxygen consumption (CMRO2). Due to low MR-sensitivity of the
17O-nucleus, spatial as well as temporal resolution is limited. Induced partial
volume effects hinder accurate and stable signal quantification which is
essential for dynamic studies. High resolution 17O-data with (4.5mm)3 was
acquired with a Golden Angle acquisition scheme which allowed reconstruction of
arbitrary time-frames. A partial volume correction algorithm was applied to
test correction capability of data of different temporal resolution.
