Christiaan Hendrik Bas van Niftrik1, Marco Piccirelli2, Jan-Karl Burkhardt1, Athina Pangalu2, Antonio Valavanis2, Michael Weller3, Oliver Bozinov1, Luca Regli1, and Jorn Fierstra1
1Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland, 2Department of Neuroradiology, University Hospital Zurich, Zurich, Switzerland, 3Department of Neurology, University Hospital Zurich, Zurich, Switzerland
uncoupling (false negative BOLD activation) can be found in patients with high
grade gliomas. An underlying mechanism could be impaired cerebrovascular
reactivity. We determined overall cerebrovascular reactivity (CVR) as well as
the perifocal CVR and used a healthy control group. We applied an automated
tumor masking with determination of CVR in 7 consecutive rings of 3 mm.
We found an overall impaired CVR as well as significantly impaired intratumoral
CVR and perifocal up to 12 mm. No such trend was found on the contralateral
hemisphere, after flipping of the tumor mask.