Lawrence Kenning1, Martin Lowry2, Martin D Pickles1, Chris Roland Hill3, Shailendra Achawal3, and Chittoor Rajaraman3
1Centre for MR Investigations, Hull York Medical School at University of Hull, Hull, United Kingdom, 2Hull York Medical School at University of Hull, Hull, United Kingdom, 3Hull and East Yorkshire Hospitals NHS Trust, Hull, United Kingdom
DTI,
DCE and DSC MRI parameters obtained pre-surgery and post-chemoradiotherapy were
used to predict overall survival in a cohort of patients with glioblastoma
multiforme. Results suggest that preoperative diffusivity measurements contain prognostic
information about survival. Following chemoradiotherapy, Ktrans, ve,
rCBV and tumour volumes were found to have significant prognostic value with
higher values associated with shorter overall survival. Cox regression analysis
identified 2 volumes and 2 MR parameters, confirming the Kaplan-Meier findings
that preoperative DTI and post-chemoradiotherapy DCE parameters have added
prognostic value to more traditional prognostic features such as tumour volume.
