1The Ohio State University, Columbus, OH, United States, 2Radiology, Nationwide Children’s Hospital, Columbus, OH, United States, 3Center for Perinatal Research, Nationwide Children’s Hospital, Columbus, OH, United States
Gadolinium
based contrast agents decrease T1 times in pathologic regions of the
brain and improve image contrast and lesion visualization with increased
sensitivity and specificity. Magnetization
Prepared Rapid Gradient Echo (MPRAGE) sequence offer thinner slices, near
seamless reformatting options, and lower specific absorption rates than 2D
spin-echo based technique. In this
study, we optimize MPRAGE sequence using computer simulation to improve brain
tumor enhancement and detection. Compared
with a Siemens default MPRAGE sequence, our optimized protocol greatly shortened scan time by around
60% without sacrificing tumor delectation sensitivity.
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