Abstract #4378

High-resolution whole-brain intracranial vessel wall MRI at 3T: Technical considerations toward a clinically practical imaging approach to stroke etiology assessment

Zhaoyang Fan¹, Qi Yang^1,2, Zixin Deng^1,3, Shlee Song⁴, Xiuhai Guo⁵, Wouter Schievink⁶, Xiaoming Bi⁷, Gerhard Laub⁷, Patrick Lyden⁴, and Debiao Li^1,3

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Radiology, Xuanwu Hospital, Beijing, China, People's Republic of, ³Bioengineering, University of California, Los Angeles, CA, United States, ⁴Neurology, Cedars-Sinai Medical Center, Beijing, CA, United States, ⁵Neurology, Xuanwu Hospital, Beijing, China, People's Republic of, ⁶Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁷MR R&D, Siemens Healthcare, Los Angeles, CA, United States

High-resolution MR using variable-flip-angle 3D fast spin-echo (FSE) has emerged as a promising intracranial vessel wall imaging technique. However, its typical implementations on clinically available MR systems have several limitations. This work aimed to develop a 3D FSE-based method that allows for CSF-attenuated T1-weighted whole-brain vessel wall imaging within 8 min. Volunteer studies were performed during technical optimization. Preliminary clinical validation was conducted in patients with various vessel wall pathologies. The technique demonstrated excellent vessel wall delineation quality, diagnostic accuracy, and patient tolerance. It may potentially become a clinically practical imaging approach to stroke etiology assessment.

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