Demyelination and remyelination: frequency shift assessment in lysolecithin rat model
Evan I Wen Chen1, Andrew Yung2, Barry Bohnet1, Alexander Rauscher1,3, and Piotr Kozlowski1,3
1MRI Research Center, University of British Columbia, Vancouver, BC, Canada, 2Research Scientist, University of British Columbia, Vancouver, BC, Canada, 3Radiology, University of British Columbia, Vancouver, BC, Canada
GRE images provide strong gray/white matter contrast that
is determined by the local MR resonance frequency, which has been shown to be
strongly influenced by the local tissue microstructure. While studies have
looked at well-defined architectures in rat spinal cord to study this
biophysical mechanism, the specific effects of axon/myelin microstructure on
frequency shifts is difficult to evaluate independently. Using lysolecithin to
induce chemical demyelination while preserving axonal integrity, we assess predominantly
myelin-related effects on frequency shifts in rat dorsal column as it demyelinates/remyelinates,
providing insight important to applications of frequency shift mapping to
demyelinating diseases such as multiple sclerosis.
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