Abstract #4463

Comparison of vertebral bone marrow water ADC between young and old subjects: DW-MRS versus DWI

Michael Dieckmeyer¹, Stefan Ruschke¹, Hendrik Kooijman², Ernst J. Rummeny¹, Jan S. Kirschke³, Thomas Baum¹, and Dimitrios C. Karampinos¹

¹Diagnostic and Interventional Radiology, Technische Universität München, Munich, Germany, ²Philips Research Laboratory, Hamburg, Germany, ³Neuroradiology, Technische Universität München, Munich, Germany

The apparent diffusion coefficient (ADC) of vertebral bone marrow has been proposed as a useful biomarker for differentiating between benign and malignant vertebral compression fractures and could potentially be beneficial for the understanding of physiological as well as pathological bone marrow changes. In this work we exploit the spectral resolution of diffusion weighted magnetic resonance spectroscopy (DW-MRS) to exclusively quantify the ADC of the bone marrow water component and compare it to DWI based measurements. The results of two age groups are compared.

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