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Abstract #0117

Free-breathing R2* Characterization of the Placenta During Normal Early Gestation Using a Multiecho 3D Stack-of-Radial Technique

Tess Armstrong1,2, Dapeng Liu1, Thomas Martin1,2, Alto Stemmer3, Yutaka Natsuaki4, Sherin U. Devaskar5, Carla Janzen6, Teresa Chanlaw5, Rinat Masamed1, Daniel Margolis7, Kyunghyun Sung1,2, and Holden H. Wu1,2

1Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, 2Physics and Biology in Medicine, University of California Los Angeles, Los Angeles, CA, United States, 3Siemens Healthcare GmbH, Erlangen, Germany, 4Siemens Healthcare, Los Angeles, CA, United States, 5Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 6Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, 7Radiology, Weill Cornell Medical College, New York, NY, United States

Abnormal placental vascular development leads to ischemic-hypoxia thereby causing fetal growth restriction, preterm labor, and spontaneous abortion. Multiecho Cartesian MRI can characterize placental hypoxia by quantifying R2*, but is susceptible to motion artifacts. We have developed a new free-breathing (FB) multiecho R2* quantification technique using 3D stack-of-radial imaging (Radial). In n=16 subjects as part of an IRB-approved study, we observed an R2* range of 5 – 30s-1 at 3 T using the new FB Radial technique in the placenta during early normal gestation. Our new technique and the measured normative range of R2* may improve management of pregnancies with placental ischemic-hypoxia.

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