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Abstract #0118

Respiratory $$$\alpha$$$-mapping of cystic fibrosis at 1.5T

Orso Pusterla1,2, Grzegorz Bauman1,2, Sylvia Nyilas3, Philipp Madörin1, Bernd Jung4, Michael Ith4, Enno Stranzinger4, Urs Frey5, Philipp Latzin3, and Oliver Bieri1,2

1Department of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, Switzerland, 2Department of Biomedical Engineering, University of Basel, Basel, Switzerland, 3Division of Respiratory Medicine, Department of Pediatrics, University Children's Hospital of Bern, Bern, Switzerland, 4University Institute for Diagnostic, Interventional and Pediatric Radiology, Bern University Hospital, Bern, Switzerland, 5Department of Pediatric Pneumology, University Children's Hospital Basel, Basel, Switzerland

Respiratory $$$\alpha$$$-mapping is based on native 1H multi-volumetric ultra-fast balanced steady-state free precession (ufSSFP) breath-hold imaging of the lung and provides whole lung isotropic pulmonary ventilation-related information. In this work, respiratory $$$\alpha$$$-mapping is evaluated in pediatric patients with cystic fibrosis (CF) and compared to functional lung parameters from nitrogen multiple-breath washout (N2-MBW). The percentage of respiratory $$$\alpha$$$-impairments measured with $$$\alpha$$$-mapping is strongly correlated with the lung clearance index (LCI), a parameter for global ventilation inhomogeneity.

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