Abstract #0198

Measuring APT contrast in the lung using CEST FT-phase MRI and a retrospective gating technique

Kyle M. Jones¹, Carol A. Steum², Charles C. Hsu³, Phillip H. Kuo², Mark D. Pagel², and Edward A. Randtke²

¹Biomedical Engineering, University of Arizona, Tucson, AZ, United States, ²Medical Imaging, University of Arizona, Tucson, AZ, United States, ³Medicine, University of Arizona, Tucson, AZ, United States

We have developed a CEST FT-phase MRI method that can measure endogenous Amide Proton Transfer (APT) contrast in lung tumors and other tissues that are affected by lung motion. The method monitors the breathing cycle based on the relative phase angle between adjacent pixels, and selects a subset of images during the quiescent period between breaths. The resulting MTR_asym contrast of an oscillating egg white phantom, volunteers, and patients with lung tumors showed that CEST FT-phase MRI produced more precise quantitative assessments of APT.

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