Abstract #0199

B1+ inhomogeneity mitigation in CEST using parallel transmission: pTxCEST

Nuno André da Silva¹, Desmond H. Y. Tse², Benedikt A Poser², and N Jon Shah^1,3,4

¹Institute of Neuroscience and Medicine - 4, Forschungszentrum Jülich, Jülich, Germany, ²Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands, ³Department of Neurology, Faculty of Medicine, RWTH Aachen University, JARA, Aachen, Germany, ⁴Department of Electrical and Computer Systems Engineering, and Monash Biomedical Imaging, School of Psychological Sciences, Monash University, Melbourne, Australia

To demonstrate the benefits from the increased spectral bandwidth at ultra-high field (UHF) by using parallel transmission (pTx) to mitigate flip-angle inhomogeneity in chemical exchange saturation transfer (CEST) imaging. A pTx basis pulse is homogenised by magnitude least-squares (MLS) optimisation and expanded to form a frequency-selective saturation pulse for CEST. The pTx saturation pulse was validated by both Bloch-McConnell simulation and in vivo imaging at 7T. Improved homogeneity in contrasts and relaxation-compensated CEST metrics were observed in our in vivo data when the pTx saturation pulse was used instead of the standard CP-mode Gaussian pulse.

This abstract and the presentation materials are available to members only; a login is required.

Join Here