Time dependence of microscopic anisotropy measured with diffusion MRI can reveal the cellular eccentricity at different lengths scales, which is an important step towards the goal of non-invasive characterization of tissue microstructure. Diffusion sequences which vary the gradient orientation within one measurement can probe microscopic anisotropy, regardless of the macroscopic tissue configuration. Here we employ the newly proposed Double Oscillating Diffusion Encoding (DODE) sequences, consisting of two independent trains of oscillating gradients which can have different orientations, in order to measure the time dependence of microscopic anisotropy in the mouse brain.
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