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Abstract #0557

In vivo metabolic imaging of neuroinflammation following traumatic brain injury using hyperpolarized [1-13C] pyruvate

Caroline Guglielmetti1,2, Austin Chou1,2, Karen Krukowski1,2, Maria Serena Paladini1,2, Lara-Kirstie Riparip1,2, Susanna Rosi1,2,3, and Myriam Chaumeil2,4

1Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, United States, 2Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, United States, 3Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States, 4Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States

This study demonstrates that metabolic imaging of hyperpolarized [1-13C] pyruvate can detect increased hyperpolarized lactate production in vivo in a preclinical model of Traumatic Brain Injury. Correlative assays further demonstrate that this increased lactate is linked to the presence of pro-inflammatory macrophages that upregulate pyruvate dehydrogenase kinase 1, subsequently leading to regional pyruvate dehydrogenase inhibition. Metabolic imaging of hyperpolarized [1-13C] pyruvate thus has great potential to provide a novel tool for in vivo detection of neuroinflammation.

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