Renal stiffness was investigated using multifrequency MRE in healthy controls and patients with IgA nephropathy. Patients show a reduced renal stiffness as compared to healthy controls. DWI and BOLD imaging were also applied to the subjects. Both ADC and T2* were linearly correlated with wave speed obtained from MRE. By mechanical vascular-solid tissue interactions, wave speed measurements by multifrequency MRE offer a quantitative measure for the noninvasive assessment renal function.