Abstract #0857

Improving Amide Proton Transfer (APT) MRI Quantification in Acute Human Stroke Patients: Achieving More Pure APT Signals and Higher Detection Sensitivity

Hye-Young Heo^1,2, Yi Zhang¹, Tina Burton³, Shanshan Jiang¹, Peter C.M. van Zijl^1,2, Richard Leigh³, and Jinyuan Zhou^1,2

¹Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Stroke Diagnostics and Therapeutics Section, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD, United States

APT-weighted (APTw) imaging based on MTR asymmetry analysis has shown promise for identifying ischemic lesions, but suffers from low accuracy due to small APTw intensity changes, Quantitative APT, nuclear overhauser enhancement (NOE), perfusion and diffusion MRI were performed on acute stroke patients (n=30). The results showed that while APTw MRI for pH analysis based on MTR_asym analysis was confounded by upfield NOE effects, NOE-free APT-MRI contrast between normal and ischemic lesions was substantially increased, nearly 3 times larger than that based on MTR_asym analysis. Furthermore, noticeable NOE contrast was observed for lesions, explained in terms of a relayed-NOE transfer mechanism.

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