Spatiotemporal quantification of reporter gene expression in the mouse heart using the Lysine Rich Protein and cardiac chemical exchange saturation transfer
Shelby Meier1, Jose Abisambra2, J Brandon3, Assaf Gilad4, and Moriel Vandsburger1,5
1Physiology, University of Kentucky, Lexington, KY, United States, 2Physiology, University of Kentucky, 3University of Kentucky, 4Radiology and Radiological Sciences, Johns Hopkins University, 5Bioengineering, U.C. Berkeley, Berkeley, CA, United States
We utilized cardiac chemical exchange saturation transfer MRI and an artificial reporter gene, the Lysine Rich Protein (LRP), to image gene transfer in the mouse heart using 2 routes of viral vector administration.
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