The link between diabetes and dysregulation of OATP transporters provides an avenue for imaging the disease with MRI. The aim of this work was to use DCE-MRI to non-invasively measure decreases of OATPs during the onset of diabetes. The data presented here verifies that both Gd-EOB-DTPA and Gd-BOPTA enhanced MRI reveals underlying alterations in OATPs that are present in the liver and kidney as a result of diabetes. Preliminary data further suggests that there could be a link between changes in organ enhancement and disease onset. Thus, there is the potential to monitor diabetes and perhaps even diagnose pre-diabetes.