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Abstract #1073

Preliminary Analysis of Longitudinal Functional MRI Data in Diabetic Nephropathy and Healthy Controls

Lu-Ping Li1,2, Jon Thacker3, Wei Li1,2, Huan Tan1, Chi Wang4, Orly Kohn5, Stuart Sprague1,2, and Pottumarthi Prasad1,2

1Northshore University HealthSystem, Evanston, IL, United States, 2Pritzker School of Medicine, University of Chicago, Chicago, IL, United States, 3Biomedical Engineering, Northwestern Univerisity, Evanston, IL, United States, 4Research Institute, Northshore University HealthSystem, Evanston, IL, United States, 5University of Chicago, Chicago, IL, United States

BOLD, Diffusion and ASL MRI data were acquired in diabetic nephropathy (DN) patients with stage-3 chronic kidney disease and healthy subjects. Consistent with the chronic hypoxia model for progression of DN, kidneys in subjects with DN had significantly lower blood flow and medullary R2* compared to controls. Intra-subject coefficient of variation (CV) for R2* and ADC was less than 10% in the control group when comparing baseline and 18 month data, suggests R2* and ADC measurements were reproducible over 18 month. CV was higher for blood flow.

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